①Brenner tumour
Brenner瘤
Definition
Brenner tumour is a tumour composed of nests of bland transitional/urothelial epithelium set within a dense fibromatousstroma.
定義
Brenner瘤是一種由溫和的移行上皮/尿路上皮細胞巢組成的腫瘤,位于致密的纖維瘤性間質(zhì)中。
ICD-O coding
9000/0 Brenner tumour NOS
ICD-O編碼
9000/0 Brenner瘤NOS
Essential and desirable diagnostic criteria
Essential: tumours with nests of bland transitional/urothelial epithelium set within fibromatous stroma.
必需和理想的診斷標準
必需:形態(tài)溫和的移行/尿路上皮細胞巢位于纖維瘤性間質(zhì)中。
Fig.1.58 Brenner tumour. Small nests and cysts in a fibromatous background.
圖1.58 Brenner瘤。小巢狀和囊性結(jié)構(gòu)位于纖維瘤性背景中。
Fig. 1.59 Brenner tumour. A Transitional/urothelial nests (some of which show cyst formation) are in a fibromatous stroma. B Characteristic cytological features include uniform oval cells with pale cytoplasm, nuclei with occasional grooves, fine chromatin, and small nucleoli.
圖1.59 Brenner瘤。A移行/尿路上皮巢(其中部分有囊腔形成)位于纖維瘤性間質(zhì)中。B細胞學特征包括一致的卵圓形細胞,胞質(zhì)淡染,偶有核溝,染色質(zhì)細,核仁小。
②Borderline Brenner tumour
交界性Brenner瘤
Definition
Borderline Brenner tumour is a tumour of transitional/urothelial epithelium displaying papillary architecture and lacking stromal invasion.
定義
交界性Brenner瘤是一種移行/尿路上皮腫瘤,呈現(xiàn)乳頭狀結(jié)構(gòu),缺乏間質(zhì)浸潤。
ICD-O coding
9000/1 Brenner tumour, borderline malignancy
ICD-O編碼
9000/1Brenner瘤,交界性惡性腫瘤
Essential and desirable diagnostic criteria
Essential: papillary growth resembling low-grade papillary urothelial neoplasms of the urothelial tract or (rarely) crowded nests of transitional/urothelial epithelium, without stromal invasion.
Desirable: a benign Brenner component.
必需和理想的診斷標準
基本特征:乳頭狀生長,類似于尿路低級別乳頭狀尿路上皮腫瘤,或(罕見)擁擠的移行/尿路上皮巢,無間質(zhì)浸潤。
理想的:良性Brenner瘤成分。
Fig. 1.60 Borderline Brenner tumour. A This tumour shows a prominent papillary growth pattern. B The papillae are lined by transitional-type epithelium with scattered pleomorphic cells.
圖1.60交界性Brenner瘤。A腫瘤呈明顯的乳頭狀生長。B乳頭襯覆移行上皮,其中有散在的多形性細胞。
Fig. 1.61 Borderline Brenner tumour. A This tumour shows an endophytic, ribbon-like growth pattern. B Cytologically, this tumour shows uniform transitional-type epithelium.
圖1.61交界性Brenner瘤。A腫瘤顯示內(nèi)生性、帶狀生長模式。B細胞學上,該腫瘤顯示一致的移行上皮。
③Malignant Brenner tumour
惡性Brenner瘤
Definition
Malignant Brenner tumour is anovariancarcinoma resembling an invasive urothelial carcinoma, associated with benign or borderline Brenner tumour.
定義
惡性Brenner瘤是一種類似于浸潤性尿路上皮癌的卵巢癌,與良性或交界性Brenner瘤相關(guān)。
ICD-O coding
9000/3 Brenner tumour, malignant
ICD-O編碼
9000/3 Brenner瘤,惡性
Essential and desirable diagnostic criteria
Essential: Malignant tumour with urothelial differentiation; a benign or borderline Brenner tumour component in the background.
必需和理想的診斷標準
必需:惡性腫瘤伴尿路上皮分化;背景中有良性或交界性Brenner瘤成分。
Fig. 1.62 Malignant Brenner tumour. A Solid confluent and papillary tumour growth with residues of a benign Brenner tumour at the lower edge. B Confluent sheets of tumour with solid growth and pseudoglandular structures. C GATA3 is positive in the esidual benign component but lost in the malignant Brenner tumour.
圖1.62惡性Brenner瘤。A腫瘤呈實性融合和乳頭狀生長,下方有良性Brenner瘤殘余。B腫瘤融合成片,實性生長和假腺樣結(jié)構(gòu)。C GATA3在殘余的良性腫瘤中呈陽性,但在惡性Brenner瘤中呈陰性。
整理:南瓜子兒
審核:樊月
設(shè)計:鵬飛
編輯:雅蕓
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